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Peripheral arterial disease

MedGen UID:
352846
•Concept ID:
C1704436
•
Disease or Syndrome
Synonyms: Arterial Disease, Peripheral; Arterial Diseases, Peripheral; Artery Disease, Peripheral; Artery Diseases, Peripheral; Disease, Peripheral Arterial; Disease, Peripheral Artery; Diseases, Peripheral Arterial; Diseases, Peripheral Artery; Peripheral Arterial Disease; Peripheral Arterial Diseases; Peripheral Artery Disease; Peripheral Artery Diseases
SNOMED CT: Peripheral arterial vascular disease (840580004); Peripheral arterial disease (840580004); Peripheral artery disease (840580004)
 
Monarch Initiative: MONDO:0005386

Definition

A disorder of the arteries supplying the upper and lower extremity and the visceral organs. This includes the mesenteric arteries, the renal arteries and the aorta and excludes cerebrovascular arterial disease. Patients experience cramping and pain usually in the calves and thighs while walking. The symptoms subside with rest. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPeripheral arterial disease

Professional guidelines

PubMed

KDIGO Clinical Practice Guideline on the Evaluation and Management of Candidates for Kidney Transplantation.
Chadban SJ, Ahn C, Axelrod DA, Foster BJ, Kasiske BL, Kher V, Kumar D, Oberbauer R, Pascual J, Pilmore HL, Rodrigue JR, Segev DL, Sheerin NS, Tinckam KJ, Wong G, Knoll GA
Transplantation 2020 Apr;104(4S1 Suppl 1):S11-S103. doi: 10.1097/TP.0000000000003136. PMID: 32301874
Chronic Wounds: Evaluation and Management.
Bowers S, Franco E
Am Fam Physician 2020 Feb 1;101(3):159-166. PMID: 32003952
General cardiovascular risk profile for use in primary care: the Framingham Heart Study.
D'Agostino RB Sr, Vasan RS, Pencina MJ, Wolf PA, Cobain M, Massaro JM, Kannel WB
Circulation 2008 Feb 12;117(6):743-53. Epub 2008 Jan 22 doi: 10.1161/CIRCULATIONAHA.107.699579. PMID: 18212285

Curated

UK NICE Clinical Guideline CG147, Peripheral arterial disease: diagnosis and management

Recent clinical studies

Etiology

Peripheral artery disease: Update on etiology, pathophysiology, diagnosis and treatment.
Mandaglio-Collados D, Marín F, Rivera-Caravaca JM
Med Clin (Barc) 2023 Oct 27;161(8):344-350. Epub 2023 Jul 28 doi: 10.1016/j.medcli.2023.06.005. PMID: 37517924
Peripheral Artery Disease: A Comprehensive Updated Review.
Shamaki GR, Markson F, Soji-Ayoade D, Agwuegbo CC, Bamgbose MO, Tamunoinemi BM
Curr Probl Cardiol 2022 Nov;47(11):101082. Epub 2021 Dec 11 doi: 10.1016/j.cpcardiol.2021.101082. PMID: 34906615
Peripheral Artery Disease: Past, Present, and Future.
Campia U, Gerhard-Herman M, Piazza G, Goldhaber SZ
Am J Med 2019 Oct;132(10):1133-1141. Epub 2019 May 29 doi: 10.1016/j.amjmed.2019.04.043. PMID: 31150643
Lower Extremity Peripheral Artery Disease: Diagnosis and Treatment.
Firnhaber JM, Powell CS
Am Fam Physician 2019 Mar 15;99(6):362-369. PMID: 30874413
2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS): Document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteriesEndorsed by: the European Stroke Organization (ESO)The Task Force for the Diagnosis and Treatment of Peripheral Arterial Diseases of the European Society of Cardiology (ESC) and of the European Society for Vascular Surgery (ESVS).
Aboyans V, Ricco JB, Bartelink MEL, Björck M, Brodmann M, Cohnert T, Collet JP, Czerny M, De Carlo M, Debus S, Espinola-Klein C, Kahan T, Kownator S, Mazzolai L, Naylor AR, Roffi M, Röther J, Sprynger M, Tendera M, Tepe G, Venermo M, Vlachopoulos C, Desormais I; ESC Scientific Document Group
Eur Heart J 2018 Mar 1;39(9):763-816. doi: 10.1093/eurheartj/ehx095. PMID: 28886620

Diagnosis

Peripheral Artery Disease: A Comprehensive Updated Review.
Shamaki GR, Markson F, Soji-Ayoade D, Agwuegbo CC, Bamgbose MO, Tamunoinemi BM
Curr Probl Cardiol 2022 Nov;47(11):101082. Epub 2021 Dec 11 doi: 10.1016/j.cpcardiol.2021.101082. PMID: 34906615
Peripheral Artery Disease: Past, Present, and Future.
Campia U, Gerhard-Herman M, Piazza G, Goldhaber SZ
Am J Med 2019 Oct;132(10):1133-1141. Epub 2019 May 29 doi: 10.1016/j.amjmed.2019.04.043. PMID: 31150643
Lower Extremity Peripheral Artery Disease: Diagnosis and Treatment.
Firnhaber JM, Powell CS
Am Fam Physician 2019 Mar 15;99(6):362-369. PMID: 30874413
Peripheral Arterial Disease.
Conte SM, Vale PR
Heart Lung Circ 2018 Apr;27(4):427-432. Epub 2017 Nov 7 doi: 10.1016/j.hlc.2017.10.014. PMID: 29150158
2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS): Document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteriesEndorsed by: the European Stroke Organization (ESO)The Task Force for the Diagnosis and Treatment of Peripheral Arterial Diseases of the European Society of Cardiology (ESC) and of the European Society for Vascular Surgery (ESVS).
Aboyans V, Ricco JB, Bartelink MEL, Björck M, Brodmann M, Cohnert T, Collet JP, Czerny M, De Carlo M, Debus S, Espinola-Klein C, Kahan T, Kownator S, Mazzolai L, Naylor AR, Roffi M, Röther J, Sprynger M, Tendera M, Tepe G, Venermo M, Vlachopoulos C, Desormais I; ESC Scientific Document Group
Eur Heart J 2018 Mar 1;39(9):763-816. doi: 10.1093/eurheartj/ehx095. PMID: 28886620

Therapy

Effect of Omega-3 Dosage on Cardiovascular Outcomes: An Updated Meta-Analysis and Meta-Regression of Interventional Trials.
Bernasconi AA, Wiest MM, Lavie CJ, Milani RV, Laukkanen JA
Mayo Clin Proc 2021 Feb;96(2):304-313. Epub 2020 Sep 17 doi: 10.1016/j.mayocp.2020.08.034. PMID: 32951855
Association between sodium-glucose cotransporter 2 (SGLT2) inhibitors and lower extremity amputation: A systematic review and meta-analysis.
Heyward J, Mansour O, Olson L, Singh S, Alexander GC
PLoS One 2020;15(6):e0234065. Epub 2020 Jun 5 doi: 10.1371/journal.pone.0234065. PMID: 32502190Free PMC Article
The Evolving Future of PCSK9 Inhibitors.
Rosenson RS, Hegele RA, Fazio S, Cannon CP
J Am Coll Cardiol 2018 Jul 17;72(3):314-329. Epub 2018 Jul 9 doi: 10.1016/j.jacc.2018.04.054. PMID: 30012326
Riferminogene pecaplasmide.
Am J Cardiovasc Drugs 2010;10(5):343-6. doi: 10.2165/11533480-000000000-00000. PMID: 20860417
Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients.
Antithrombotic Trialists' Collaboration
BMJ 2002 Jan 12;324(7329):71-86. doi: 10.1136/bmj.324.7329.71. PMID: 11786451Free PMC Article

Prognosis

Global trends in diabetes complications: a review of current evidence.
Harding JL, Pavkov ME, Magliano DJ, Shaw JE, Gregg EW
Diabetologia 2019 Jan;62(1):3-16. Epub 2018 Aug 31 doi: 10.1007/s00125-018-4711-2. PMID: 30171279
Major Adverse Limb Events and Mortality in Patients With Peripheral Artery Disease: The COMPASS Trial.
Anand SS, Caron F, Eikelboom JW, Bosch J, Dyal L, Aboyans V, Abola MT, Branch KRH, Keltai K, Bhatt DL, Verhamme P, Fox KAA, Cook-Bruns N, Lanius V, Connolly SJ, Yusuf S
J Am Coll Cardiol 2018 May 22;71(20):2306-2315. Epub 2018 Mar 11 doi: 10.1016/j.jacc.2018.03.008. PMID: 29540326
Peripheral Arterial Disease.
Conte SM, Vale PR
Heart Lung Circ 2018 Apr;27(4):427-432. Epub 2017 Nov 7 doi: 10.1016/j.hlc.2017.10.014. PMID: 29150158
Epidemiology of peripheral artery disease.
Criqui MH, Aboyans V
Circ Res 2015 Apr 24;116(9):1509-26. doi: 10.1161/CIRCRESAHA.116.303849. PMID: 25908725
Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1·9 million people.
Shah AD, Langenberg C, Rapsomaniki E, Denaxas S, Pujades-Rodriguez M, Gale CP, Deanfield J, Smeeth L, Timmis A, Hemingway H
Lancet Diabetes Endocrinol 2015 Feb;3(2):105-13. Epub 2014 Nov 11 doi: 10.1016/S2213-8587(14)70219-0. PMID: 25466521Free PMC Article

Clinical prediction guides

Arterial pathologies in athletes.
Peach G, Sinha S, Hinchliffe RJ
J Cardiovasc Surg (Torino) 2017 Apr;58(2):360-368. Epub 2017 Jan 4 doi: 10.23736/S0021-9509.17.09853-6. PMID: 28051290
2016 AHA/ACC Guideline on the Management of Patients With Lower Extremity Peripheral Artery Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Gerhard-Herman MD, Gornik HL, Barrett C, Barshes NR, Corriere MA, Drachman DE, Fleisher LA, Fowkes FG, Hamburg NM, Kinlay S, Lookstein R, Misra S, Mureebe L, Olin JW, Patel RA, Regensteiner JG, Schanzer A, Shishehbor MH, Stewart KJ, Treat-Jacobson D, Walsh ME
Circulation 2017 Mar 21;135(12):e686-e725. Epub 2016 Nov 13 doi: 10.1161/CIR.0000000000000470. PMID: 27840332Free PMC Article
Inflammatory biomarkers in peripheral arterial disease.
Stone PA, Yacoub M
Semin Vasc Surg 2014 Dec;27(3-4):148-51. Epub 2015 Jan 29 doi: 10.1053/j.semvascsurg.2015.01.009. PMID: 26073823
Therapy-centered classification of peripheral arterial disease.
Rümenapf G, Huppert P, Schulte KL, Lawall H
Vasa 2014 Jan;43(1):3-5. doi: 10.1024/0301-1526/a000323. PMID: 24429326
Peripheral arterial calcification: prevalence, mechanism, detection, and clinical implications.
Rocha-Singh KJ, Zeller T, Jaff MR
Catheter Cardiovasc Interv 2014 May 1;83(6):E212-20. Epub 2014 Feb 10 doi: 10.1002/ccd.25387. PMID: 24402839Free PMC Article

Recent systematic reviews

Antithrombotic Therapy for Symptomatic Peripheral Arterial Disease: A Systematic Review and Network Meta-Analysis.
Willems LH, Maas DPMSM, Kramers K, Reijnen MMPJ, Riksen NP, Ten Cate H, van der Vijver-Coppen RJ, de Borst GJ, Mees BME, Zeebregts CJ, Hannink G, Warlé MC
Drugs 2022 Aug;82(12):1287-1302. Epub 2022 Aug 23 doi: 10.1007/s40265-022-01756-6. PMID: 35997941Free PMC Article
KDIGO Clinical Practice Guideline on the Evaluation and Management of Candidates for Kidney Transplantation.
Chadban SJ, Ahn C, Axelrod DA, Foster BJ, Kasiske BL, Kher V, Kumar D, Oberbauer R, Pascual J, Pilmore HL, Rodrigue JR, Segev DL, Sheerin NS, Tinckam KJ, Wong G, Knoll GA
Transplantation 2020 Apr;104(4S1 Suppl 1):S11-S103. doi: 10.1097/TP.0000000000003136. PMID: 32301874
Global, regional, and national prevalence and risk factors for peripheral artery disease in 2015: an updated systematic review and analysis.
Song P, Rudan D, Zhu Y, Fowkes FJI, Rahimi K, Fowkes FGR, Rudan I
Lancet Glob Health 2019 Aug;7(8):e1020-e1030. doi: 10.1016/S2214-109X(19)30255-4. PMID: 31303293
Global vascular guidelines on the management of chronic limb-threatening ischemia.
Conte MS, Bradbury AW, Kolh P, White JV, Dick F, Fitridge R, Mills JL, Ricco JB, Suresh KR, Murad MH; GVG Writing Group
J Vasc Surg 2019 Jun;69(6S):3S-125S.e40. Epub 2019 May 28 doi: 10.1016/j.jvs.2019.02.016. PMID: 31159978Free PMC Article
Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysis.
Fowkes FG, Rudan D, Rudan I, Aboyans V, Denenberg JO, McDermott MM, Norman PE, Sampson UK, Williams LJ, Mensah GA, Criqui MH
Lancet 2013 Oct 19;382(9901):1329-40. Epub 2013 Aug 1 doi: 10.1016/S0140-6736(13)61249-0. PMID: 23915883

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    Clinical resources

    Practice guidelines

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    Curated

    • NICE, 2020
      UK NICE Clinical Guideline CG147, Peripheral arterial disease: diagnosis and management

    Consumer resources

    Reviews

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